Epub 2012 Jul 4. Vazquez-Carballo A, Ceperuelo-Mallafre V, Chacon MR, et al. 2013 Sep 11;4:130. doi: 10.3389/fneur.2013.00130. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. This article outlines an anti-inflammatory diet plan that is based on science. Though more rigorous human studies are needed, the polyphenol shows promise as an anticancer therapy in humans (20). Shen Y, Pang EC, Xue CC, Zhao ZZ, Lin JG, Li CG. However, use the extract only after consulting a medical professional. Research on honokiol has found that it can reduce inflammation in the brain and spinal cord specifically, partly due to its ability to cross the blood-brain barrier (14). 1The Second Hospital of Jilin University, Changchun 130041, China, 2The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA, 3School of Public Health, Jilin University, Changchun 130021, China, 4The First Hospital of Jilin University, Changchun 130021, China, 5Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park, Pudong, Shanghai 201201, China, 6Bioland R&D Center, 59 Songjeongni 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea. 1994 Feb 9;47(3):549-53. doi: 10.1016/0006-2952(94)90187-2. It is generally considered safe if taken orally and for the short term. It does help relax me and it does seem to relieve the kidney pain. Weakness. Obesity is considered as a state of chronic low-grade systemic inflammation and oxidative stress, which interact with each other and cause a vicious circle, promoting the development of insulin resistance [19, 20]. Skin rash has been reported with the use of cosmetics containing magnolia bark extract. In THP-1 cells, magnolol and honokiol reduced inflammatory TNF- and IL-8 production induced by Propionibacterium acnes (3). Help WordReference: Ask in the forums yourself. Western blot assay were performed for measuring the expression of inflammatory cytokines and TNF- (a) and PAI-1 (b). For example, 4-O-methylhonokiol, a novel compound isolated from Magnolia officinalis, prevents the development and progression of Alzheimer's disease by improving oxidative stress through a p38 MAPK-dependent pathway [25]. Therefore, magnolia bark could be used as a remedy for insomnia or simply to promote better sleep overall. Bethesda, MD 20894, Web Policies Honokiol is a potent scavenger of superoxide and peroxyl radicals. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. I bought this item because I read a scientific study which said that magnolia bark extract has been able to stop kidney disease from progressing. Pharmacology & Therapeutics, May 2011; vol 130: pp 157-176. PDF Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells. Sarrica A, Kirika N, Romeo M, Salmona M, Diomede L. Safety and Toxicology of Magnolol and Honokiol. Corticosterone and serotonin each play a role in regulating anxiety, mood, and depression. Thyroid dysfunction is reported as one of the side effects of supplementation with magnolia bark. n = 5; *P < 0.05 versus LFD group; # Then they begin to develop and destroy the tissues of the tree. Magnolia bark for dental health. This article reviews the, Sorrel, which refers to both a leafy green plant and its fruit, is known for its tart taste and powerful health benefits. The next study was to explore the possible mechanism by which BL153 attenuates kidney inflammation and oxidative stress in obesity. Weisinger RS, Stanley TK, Begg DP, Weisinger HS, Spark KJ, Jois M. Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet. Contact dermatitis: In 4 patients following application of magnolia extract-containing cosmetics(44)(45). Therefore, compounds such as BL153, with therapeutic efficacy and distinct mechanisms from MG132 and sulforaphane, have great potential for treatment of obesity-associated nephropathy. Phytotherapy has been used for human disease as an alternative or complement to allopathic medicines for several centuries [8, 9]. Antitumor and antiangiogenic properties of honokiol are attributed to NF-kB inhibition and the consequent scavenging of reactive oxygen species(24). EDRF-release and Ca+(+)-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb. 2012 Nov;63(6):1191-9. doi: 10.1016/j.neuropharm.2012.06.031. Clark AM, El-Feraly FS, Li WS. In addition, we also investigated the protective effects of BL153 on obesity-induced oxidative stress by examining 3-nitrotyrosine (3-NT, Figure 4(a)) as an index of nitrosative damage and 4-hydroxy-2-nonenal (4-HNE, Figure 4(b)) as an index of oxidative damage in the next study. Importantly, BL153 treatment attenuated obesity caused renal inflammation and oxidative stress, which was likely due to the ability of BL153 to increase PGC-1 and HK II expression in kidney. Epub 2013 Aug 23. I want to help other fitness enthusiasts in their journey to a healthier lifestyle and avoid wasting their time on ineffective supplements the same way I did in the past. The bark, leaves, and flower buds of the Magnolia tree have many medicinal uses that have been studied in medical literature, including the following: In the video below, Dr. Lindsey talks about the benefits of Magnolia Bark Extract: This is our recommended Magnolia supplement (Amazons Choice): The following are some side effects of magnolia bark: These side effects are rare and magnolia bark is safe for most adults for short-term use for up to 1 year. Int J Mol Sci. An official website of the United States government. Protein bands were visualized using enhanced chemiluminescence (Thermo scientific, Rockford, IL). Chest pain or pressure. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. As blood moves through the body, it picks up extra fluid, chemicals and waste. Also, it creates effects similar to the benzodiazepine class of drugs which can result in dependency. n = 5; *P < 0.05 versus LFD group; # Kidney tissue was fixed overnight in 10% phosphate-buffered formalin and then dehydrated in a graded alcohol series, cleared with xylene, embedded in paraffin, and sectioned at 5m thickness for pathological staining. Hypertension. Inflammation and oxidative stress play an important role in obesity-induced renal damage; hence, we performed western blot assay for the renal expression of inflammatory cytokines, tumor necrosis factor-alpha (TNF-, Figure 3(a)), and plasminogen activator inhibitor-1 (PAI-1, Figure 3(b)), which were also well accepted as adipocytokines or adipokines [18]. If the infestation is on the branch, cut it off below the affected area. However, the mechanism underlying the generation of insulin resistance in obesity has not been fully understood. Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice. The mixture also increased serotonin metabolite levels in the frontal cortex, striatum, and nucleus accumbens at 40 mg/kg. Tweak prevents Tnf-Alpha-induced insulin resistance through Pp2a activation in human adipocytes. If the sore is on the trunk, carefully clean it with a sharp knife. Western blot assay was performed as previously reported [37]. Western blot assay were performed for measuring the oxidative damage including the accumulation of 3-NT (a) and 4-HNE (b). BL153 prevented obesity-induced renal functional changes. In addition, some research -- in humans and animals -- suggests magnolia may also be useful in these ways: Some research has suggested some other possible benefits for magnolia: It might also help treat or prevent: Supplement makers may suggest varying amounts of their product for different purposes. Lastly, a study in rodents noted that a mixture of honokiol and magnolol caused antidepressant-like effects, including improvements in serotonin levels in the brain and reductions in corticosterone levels in the blood (26). Renal pathology was examined by using hematoxylin and eosin staining (b), and the arrows indicated glomerular enlargement and renal tubular epithelium damage. Moreover, the organic components such as magnolol and honokiol found in the extract have strong antioxidant properties, which may help fight free radicals off the skin. Wounds in the trunk from which fluid oozes. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Our website services, content, and products are for informational purposes only. There is one limitation in our study. Try to keep the water droplets away from the leaves while watering. Often it will dry out on the stem and have a whitish color. Always use a sterile pruning tool. This article reviews galangal root's benefits and safety, as well as how it, Elecampane root is a folk medicine that may have several health benefits. After the studies, researchers found that the treatment group did not gain any weight as opposed to the placebo group. I had some severe pains in my kidneys and started taking this product before bed each night. As shown in Figure 6, HK II protein expression was decreased in kidney of HFD group mice compared with LFD group mice; however, it was almost back to normal level by BL153 administration at indicated doses (Figure 6). Int J Dent Hyg. A voucher specimen was deposited at the Herbarium of Chungbuk National University, Chungbuk, Korea. Sedative and anti-anxiety agents: The constituents of, Anti-coagulants: Magnolia interferes with. A fairly large variety of pathogens can cause magnolia leaf disease. Data were collected from five animals for each group and presented as means SD. Some of the benefits of magnolia bark, such as improved sleep and mood, could be especially beneficial for women during menopause (30). Spray the leaves, petioles, and branches with an aqueous solution of copper fungicide. Usually in spring, when the weather is warm and humid, the pathogens settle on young leaves and begin to germinate. 19 Magnolia Bark Medicinal Uses (Kidney Failure Side Effects? This makes sense, as its known that GABA(A) receptor activity is closely associated with sleep (29). Faint watery spots appear on the leaves at first. A clinical trial was conducted on overweight women aged between 20-50 years. Control groups were given same volume of ddH2O with 0.05% ethanol. Tear off leaves that have more than four or five spots on them. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Some of the conditions that magnolia bark has traditionally been used to treat include asthma, anxiety, depression, stomach disorders, and inflammation (3, 4). In human trials, among nine healthy adults, those who chewed on mints laced with magnolia bark extract showed a 61% drop in bad odor-causing bacteria one hour after eating. This article reviews the science-supported benefits and side effects of magnolia bark. Oxidative stress also appears to play a significant role in many changes in the body and mind that accompany aging (11). In glioma cells, it induced autophagy and activated a p53/cyclin D1/CDK6/CDK4/E2F1-dependent pathway to induce apoptosis and cell cycle arrest(34) and in prostate cancer cells, honokiol suppressed c-Myc protein expression(30). Read more: How do you keep magnolias healthy? Chronic kidney disease can progress to end-stage kidney failure, which is fatal without artificial filtering (dialysis) or a kidney transplant. Modern research shows that it's helpful when treating various conditions like stress-induced anxiety, digestive issues . People who use benzodiazepine may use magnolia bark as a natural sedative. Data in humans are limited. Do this in dry weather so that the wound dries quickly and stays that way for at least a few days. Cui W, Li B, Bai Y, et al. This not only includes brain disorders like Alzheimers disease but also conditions like stress, anxiety, mood disorders, and depression (23). Especially for lowering stress, studies observed that consuming 500 mg of magnolia and Phellodendron bark extract per day greatly reduced cortisol levels. Lee, Y.J. Drug users may misuse magnolia bark for its feel-good effect. Seizures or coma in severe cases. kidney - English-Spanish Dictionary - WordReference.com n = 5; *P < 0.05 versus LFD group; # Received 2013 Sep 19; Revised 2013 Oct 31; Accepted 2013 Nov 6. Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors. Additionally, a test-tube study found that magnolol inhibited the growth of lung cancer cells (21, 22). Biochem Pharmacol. Interactions. Collect all of the fallen leaves around the magnolia. Ensure good air movement around the crown. 2010;33(3):427-31. doi: 10.1248/bpb.33.427. The bark contains the active constituents magnolol and honokiol. Magnolia bark can also be toxic and has been linked to kidney disease and permanent kidney failure. Controlled clinical study in menopause. Here is a closer look at some of the potential benefits of magnolia bark. Briefly, protein was separated on 10% SDS-PAGE gels and transferred to nitrocellulose membranes (Bio-Rad, Hercules, CA). Nevertheless, magnolia bark appears to be a safe therapy that may help treat menopause symptoms. Fraser R, Ingram MC, Anderson NH, Morrison C, Davies E, Connell JM. PMID: 29925102. Magnolia Benefits & Information (Magnolia Officinalis) - Herbwisdom 2010 Sep 16;15(9):6452-65. doi: 10.3390/molecules15096452. Older leaves are usually untouched by this disease. In summary, our results first demonstrate a therapeutic potential of BL153 in treating obesity-induced kidney disease. Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora) on cortisol and psychological mood state in moderately stressed subjects. During the six-month feeding, body weight was measured every month, and the gavage volume was justified based on the body weight change. A 2019 review study found that honokiol has shown potential to prevent tumor growth in the brain, breast, colon, liver, and skin, among other organs (17). BL153 ameliorated obesity-induced renal oxidative stress. Once cool, place the vessel overnight in a refrigerator allowing further extraction of petals. Magnolia bark extract is readily available in pill form. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. ", Natural Medicines Professional Database: "Magnolia. Small studies in humans suggest magnolia may help relieve menopausal symptoms, manage weight, and maintain oral health. P < 0.05 versus HFD group. Sulforaphane, isolated from cabbage and broccoli, is another Nrf2 activator and regulates Nrf2 by disassociating Nrf2 from its inhibitor Kelch-like ECH-associated protein 1 and subsequently facilitating Nrf2 into the nucleus [39]. Wnt/beta-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells. Magnolia bark is a popular herb in traditional Chinese and Japanese medicine. Is magnolia bark a benzodiazepine? [Fact Checked!] See additional information. In murine models, honokiol enhanced low-dose docetaxel treatment against prostate cancer growth and bone metastasis(37), and reduced breast tumor growth biomarkers(48). If you decide to supplement with magnolia bark, carefully follow the manufacturers instructions regarding how much to take and how often. Does Magnolia Bark Extract have Skin Benefits? The authors declare that they have no conflict of interests. A second study of the same magnolia and phellodendron bark extract in 56 adults observed that consuming 500 mg of the extract per day resulted in significantly lower cortisol levels and improved mood (25). Digestive problems. If the disease has affected the branch, cut it off a little closer to the trunk. Excess stress is a common problem. PMID: 22429472; PMCID: PMC3325890. Mean glomerular area was also measured to evaluate the glomerular enlargement. Molecules. The extract of the bark of Magnolia trees (Magnolia officianalis) has been used for some 1,000 years in traditional Chinese and Japanese medicine for treatment of maladies ranging from asthma to depression to headaches to muscle pain. PGC-1 promotes insulin resistance in liver through PPAR-. Rajgopal A, Missler SR, Scholten JD. HK II expression was detected by western blot assay. Magnolol demonstrated activity against a variety of cancers, including bladder(10)(11)(12), prostate(13)(14)(15)(16), colorectal(17)(18), breast(19)(20), and lung(21)(22) cancers. Magnolia Bark: How Can It Improve Your Overall Health - WebMD Urine samples were collected at the end of experiment. Statistical analysis was performed with Origin 7.5 Laboratory data analysis and graphing software. Magnolia may protect. Powdery mildew is a fungal disease that affects magnolia leaves. Magnolia bark extract Magnolol Houpu magnolia Hou Po Jump to: For Patients & Caregivers For Healthcare Professionals For Patients & Caregivers Tell your healthcare providers about any dietary supplements you're taking, such as herbs, vitamins, minerals, and natural or home remedies. Chronic kidney disease - Symptoms and causes - Mayo Clinic As mentioned, magnolia bark extract appears to have protective effects against many neurological conditions. Such leaves usually die after a while. In animal models of prostate cancer with bone metastasis, honokiol induced apoptosis via caspase-3,-8, and -9 activation and poly (ADP-ribose) polymerase (PARP) cleavage(37). Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Repeat this after 1-2 months. People have traditionally used magnolia to try to treat: Anxiety. They are used in cosmetic and weight loss products, and their use as anti-cancer, antioxidative, and anti-inflammatory agents is being studied. However, no effective medicine treating this disease is available. Magnolias are also susceptible to nectria canker, a bacterial infection that causes sunken, discolored areas of bark. This is a rather serious disease that can lead to the death of the tree if left untreated. Furthermore, this research concluded that magnolia bark extract has two main components, magnolol and honokiol, responsible for this inhibitory effect against bacteria in the mouth. Pathogens settle on the leaves and begin to destroy them. What are some Medicinal uses of the Magnolia plant? This study was supported, in part, by Chungbuk Technopark Grant Bio-International Collaborating Research, funded by Chungbuk Province, Republic of Korea, and a collaborative project between University of Louisville and Bioland Co. Ltd. for Screening Antidiabetes and/or Obesity Naturally Extracted Compounds, funded by Bioland Co., Ltd. (10-0826 Bioland). In current study, we provide the first evidence that magnolia extract, BL153, attenuates obesity-associated renal structural and functional changes in an HFD-induced obesity mouse model. Afterward, feed the tree with a multi-purpose fertilizer. How kidneys work. Clinically, it is commonly used to treat asthma, constipation, edema, abdominal distension, malaria, and other diseases by combining different traditional Chinese medicines. The beneficial effects of magnolol on learning and memory abilities were reported to be associated with superoxide dismutase (SOD) restoration in a scopolamine-induced mouse model [26]. Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of, Yu S-X, Yan R-Y, Liang R-X, Wang W, Yang B. Bioactive polar compounds from stem bark of. If wood decay progresses, use the services of a tree treatment company. The supplement has been used in traditional Chinese medicine for thousands of years, and current research has confirmed that magnolia bark has many potential benefits for humans. Then turn off the gas. Anti-bacterial: helps against acne and itching. The disease is most active during the warm summer months. This article lists 13 foods that have powerful anti-inflammatory effects to help lower chronic inflammation. However, no effective therapeutic method for obesity-associated kidney disease is available. Several distinct pathways through which insulin resistance and hyperinsulinemia lead to renal damage have been reported by overwhelming background studies, such as insulin-like growth factor 1 upregulation [4] and renin-angiotensin system activation [5]. Therefore, the effects cannot be credited to the tree bark alone. Magnolias have always been highly sought-after trees in the yard. The air-dried bark of M. officinalis (3kg) was cut into pieces and extracted twice with 95% (v/v) ethanol (4 times as much as the weight of the dried plants) for 3 days at room temperature. Magnolia Bark: Benefits, Usage, and Side Effects - Healthline PMID: 15856410. All experiments involving mice conformed to the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the University of Louisville Institutional Animal Care and Use Committee. Weisinger JR, Kempson RL, Eldridge FL, Swenson RS. Our data showed that BL153 administration did not affect HK II expression level in LFD group mice; moreover, BL153 administration in HFD group mice only increased HK II expression back to the normal level, even at a high dose (10mg/kg), indicating the safety of BL153, as illustrated in Figure 7. Magnolia Bark for Anxiety, Depression? - Ask Dr. Weil In the place where there are many of them appears rotten wood. Magnolia bark is a staple of traditional Chinese medicine and is used today for a variety of potential health benefits ranging from the treatment of depression and insomnia to improving oral health. We have reports spanning the last few decades of women developing kidney failure resulting in dialysis after using a Magnolia Bark supplement as part of a weight loss program. These findings might lead to the development of brands of gum that contain this ingredient. and transmitted securely. The supplement can be found at many online and retail stores. Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet Magnolia bark ( Magnolia officinalis) is a traditional Chinese medicine used since 100 A.D. to support the body and nurture wellbeing and to treat a plethora of ailments. Clean the wound of dead wood and wash it with fungicide. Before supplementing with magnolia bark, check with your medical provider to discuss proper dosage levels and ensure theres no risk of potential interactions with any medications youre taking.
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