Inhibition of platelet aggregation by apigenin from Apium graveolens. In one trial, dl-3-n-butylphthalide 400 mg orally daily (given as one 200 mg capsule twice daily) as part of a 90-day treatment regimen was used to improve outcomes in patients with acute ischemic stroke. Celery seed contains compounds that may be beneficial in the treatment of gout. In one animal study, researchers investigated the impact of luteolin on nitric oxide produced from uric acid. One tablespoon (6.5 grams) of celery seeds provides (2): Celery seeds are low in calories, with a tablespoon providing about 25 calories. DOI: Chandra M, et al. But more importantly, they contain components that induce apoptosis, which causes cancer cells to self-destruct (x). View abstract. Our team thoroughly researches and evaluates the recommendations we make on our site. Celery might also make the skin more sensitive to sunlight. View abstract. View abstract. Polysaccharides and antioxidants like phenolic acids and flavanols found in celery seeds fight oxidative stress and free radical damage. Some medications might make the skin more sensitive to sunlight. Puig, L. and de Moragas, J. M. Enhancement of PUVA phototoxic effects following celery ingestion: cool broth also can burn. 2005 - 2023 WebMD LLC, an Internet Brands company. ARYA Atheroscler 2016;12(5):248-9. A new French multicenter study]. View abstract. In short, celery is a plant based alternative to preserving and curing organic meat and other products. Thyroid medications: Celery seed may interact with thyroid medications. Inhibition of hepatic xanthine dehydrogenase and xanthine oxidase was suggested.Dolati 2018, Clinical trials guiding celery dosage are limited. IgE cross-reactivity between birch pollen, mugwort pollen, and celery is due to three distinct cross-reacting allergens: immunoblot investigation of the birch-mugwort-celery syndrome. J Agric Food Chem. 2004;29(2):340-6. Celery is a biennial plant that was first cultivated in Europe but is grown and consumed worldwide. 1995;49:119-126. View abstract. Celery Uses, Benefits & Dosage - Drugs.com Herbal 1983;21(2):163-165. The most notable compounds in celery seed include: These compounds have been researched for their role in inflammation and uric acid production, which is a driving force behind the severity of gout attacks. Herbal supplements and heart medicines may Indeed, celery seed is a natural alternative to synthetic repellents for protection against mosquitoes. Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. Can drinking this bright green juice really give your body a healthy boost? The essential oil produces sedative effects. Boffa, M. J., Gilmour, E., and Ead, R. D. Celery soup causing severe phototoxicity during PUVA therapy. Tuetun B, et al., Mosquito repellency of the seeds of celery (Apium graveolens L.). Celery Seed Extract: Benefits, Side Effects & Dosage, celery seed extract for high blood pressure, Ectopic Pregnancy: Characteristics, Causes & Treatment , Cayenne Pepper: Benefits, Side Effects & Dosage. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. A number of celery varieties exist, many of which are developed to meet commercial demands for particular colors, tastes, and stalk sizes. Bleeding may occur. Herbalists recommend celery for treatment of arthritis, nervousness, and hysteria. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. A celery seedflavored soda, Dr. Brown's Cel-Ray, is available. Moreover, these compounds fight against certain cancers including intestinal cancer, breast cancer and leukemia by preventing mutated malignant cells from multiplying (x). DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses. A study conducted on male rats found that celery extracts enhance sexual performance ( 23 ). Raised liver enzymes have been noted with higher doses of dl-3-n-butylphthalide, a synthesized version of an extract from seeds of A. graveolens (l-3-n-butylphthalide). In light of the fact that celery seeds may interact with some medications, including lithium, thyroid medications and blood-thinning drugs, you should consult your doctor before taking celery seed supplements (x). 2008;56(11):3997-4003. In about 450 BC, the Greeks used celery to make a type of wine called selinites, which was given as an award at early athletic games, much like laurel leaves or olive branches. Parts of the celery plant, botanically known as Apium graveolens, have been used therapeutically for thousands of years. All rights reserved. Parasitol.Res 2009;104(3):515-521. Allergy 1997;52(4):428-431. Furthermore, these compounds work together to help manage blood pressure. Reductions in plasma glucose levels were reported, but not in plasma insulin levels.Yusni 2018, A protective effect of celery leaves and seeds on gastric ulceration has been demonstrated in studies of rats.Al-Howiriny 2010, Baananou 2013, Hydroalcoholic extracts of whole A. graveolens plant may have a role in the management of gout, based on reduced serum uric acid levels in a study of rodents with induced hyperuricemia. Some studies suggest that increasing your calcium intake may reduce your risk of fractures (6, 7, 8, 9). A handful of celery seeds will help cleanse your urinary tract and keep it void of any unwanted bacteria. Boffa MJ, Gilmour E, Ead RD. 3-n-butylphthalide and beta-selinene both exhibit anti-inflammatory and antioxidant properties. Carotenoids and colon cancer. This information should not be used to decide whether or not to take this product. Celery seed has "generally recognized as safe" (GRAS) status when used as a food, according to the US Food and Drug Administration (FDA). 1995;61:18-21. 2000;71:575-582. This could increase how much lithium is in the body and result in serious side effects. Celery is POSSIBLY SAFE for most people when taken by mouth or applied to Celery seeds are a great source of non-heme iron. Gral N, Beani JC, Bonnot D, et al. All rights reserved. However, herbs can have side effects and interact with other herbs, supplements, or medications. Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Allergy, including dermatitis and anaphylaxis (rare), and phototoxicity to celery and its falcarinol content have been described.Christensen 2006, Duke 2002, Khan 2009, Pauli 1985, Raised liver enzymes have been noted in phase 3 trials of dl-3-n-butylphthalide 800 mg/day.Cui 2013, Celery seed has GRAS status when used as a food.Khan 2009 Neurotoxicity in rats due to the seed's chemical constituent falcarinol has been demonstrated.Christensen 2006 While celery root contains furocoumarins (particularly psoralens), the concentration in normal dietary intake is at least 1,000-fold lower than the no observed effect level for developing liver or cancer in rats.Dolan 2010 Limited toxicological studies suggest celery seed extract lacks toxicity at normal dosages.Powanda 2015. Theyre small, light-brown, and have an earthy scent. Coronary heart disease is the leading cause of death in many countries. One tablespoon (6.5 grams) of the seeds packs an impressive 27% of the RDI. The symptoms, likely due to a CYP2D6-dependent interaction, resolved upon cessation of the celery root extract.Khalid 2016, In a study in rats given an extract of fresh celery, increased plasma captopril levels were reported.Siska 2018, Antithrombotic effects have been described for celery seed extracts.Cui 2013 Potentiation of monoamine oxidase inhibitors is possible.Jger 2013, Agents with antiplatelet properties: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of agents with antiplatelet properties. This article explores Parmesan cheese's nutritional benefits, uses, and potential. In the UK Women's Cohort Study conducted in 13,958 women (with approximately 4 years of follow-up), consumption of an additional portion of celery (among other plants) was inversely associated with sleep duration.Noorwali 2018, Limited studies in rodents suggest celery seed extract possesses hypoglycemic effects.Yusni 2018, Very limited clinical data exist regarding the effects of celery leaf or seed extract in diabetes. Symptoms of celery allergy can afflict your mouth, with itching and swelling of the lips, tongue and throat, reports the University of Nebraska - Lincoln. Pregnant women should not use celery seed because it may lead to uterine bleeding and muscle contractions in the uterus, which could cause miscarriage. Blood thinners include aspirin, warfarin (Coumadin), and clopidogrel (Plavix). Inhibition of cell adhesion, antiangiogenic properties, proapoptosis, and other effects have been demonstrated in studies using human cancer cell lines.Iyer 2019, Kasiri 2018, Kowalczyk 2017, Sung 2016 In vitro and rodent studies suggest essential oil from celery may also possess cytotoxic and antimutagenic properties.Christensen 2006, Hashim 1994, Lim 2013, Zheng 1993, Celery extract has demonstrated vasorelaxant effects on isolated rat aortic rings.Jorge 2013 Celery seed extract exerted hypotensive effects in hypertensive, but not normotensive, rats, possibly due to the n-butylphthalide content.Moghadam 2013, Tang 2017 Limited studies in rodents report improved lipid profiles with celery seed extracts.Abd El-Mageed 2011, Iyer 2011, Iyer 2019, Rouhi-Boroujeni 2015 Additional effects in cardiovascular disease include decreased secretion of proinflammatory cytokines.Tang 2017, Limited clinical studies have been conducted to evaluate the effects of the extracted compound butylphthalide in strokeWang 2018; one study demonstrated superiority of 90-day treatment with dl-3-n-butylphthalide (a synthetic variation of l-3-n-butylphthalide, an extract from seeds of A. graveolens) over aspirin in patients with acute ischemic stroke.Cui 2013 The synthetic version of the compound is clinically approved as an anti-ischemic agent in China.Abdoulaye 2016, In older studies, 3-n-butylphthalide showed sedative and anticonvulsant effects in rodents.Khan 2009 In induced Parkinson disease models in mice, extracts from whole A. graveolens plant improved behavioral performance, oxidative stress parameters, and monoamine oxidase A and B activity.Chonpathompikunlert 2018, Huang 2010 Other studies in rodents report improvements in cognition and depression, and modulation of endogenous antioxidant and neurotransmitter systems.Boonruamkae 2017 Reviews exist regarding neuroprotective effects of the flavone luteolin, which is found in several plant products, including celery.Nabavi 2015, Clinical studies are lacking. Adv Orthop. Therapeutic Research Faculty 2020. Grape seed extract may have heart-health benefits. Eating it just a couple of times a week is best if you have a history, Once youve had a gout attack, youre more likely to have another. Late in the 19th century, various celery tonics and elixirs appeared commercially, generally containing the juice of crushed celery seeds and often with a large amount of alcohol. J.Emerg.Med. Studies do show that celery seed acts as a mosquito repellent. Celery has shown promise as a natural therapy for these and other health issues in animal studies, but remains to be proven effective in humans. J Pharm.Biomed.Anal. Cheung MC, Lin LY, Yu TH, Peng RY. As always, its important to consult your doctor before starting a new herbal supplement. Occasional consumption as part of a well-balanced diet is not an issue. Erdmann, S. M., Sachs, B., Schmidt, A., Merk, H. F., Scheiner, O., Moll-Slodowy, S., Sauer, I., Kwiecien, R., Maderegger, B., and Hoffmann-Sommergruber, K. In vitro analysis of birch-pollen-associated food allergy by use of recombinant allergens in the basophil activation test. Needless to say, regular consumption of foods high in polyphenols has been documented to combat radical damage during oxidative stress and help promote cellular longevity. Am J Health Syst Pharm 2000;57:1221-7. Today, celery seeds are most commonly used as a cooking spice. Iron deficiency is the most common micronutrient deficiency worldwide, but eating more iron-rich foods has been shown to lower your risk of deficiency and subsequent anemia (16, 17). 2023 Healthline Media LLC. Antihypertensive effect of celery seed on rat blood pressure in chronic administration. Celery is blanched to generate the edible white stem during cultivation by burying the stem. Their flavor is warm and bitter. Celery seed oil contains bergapten, which plays a part in the plants natural defense system. Here are 6 surprising benefits of celery seeds. in blood pressure. We comply with the HONcode standard for trustworthy health information. One tablespoon (6.5 grams) of the seeds provides 12% of the RDI for this mineral. View abstract. Pregnant and nursing women should avoid eating celery seeds as they may cause uterine bleeding and premature contractions (x). WebDose: to 5/8 tsp whole celery seeds, chewed/ground, with breakfast Effect on Cum Volume: Solid increase (~11%) Effect on Sperm Volume: Significant increase (~26%) Effect on Libido: Solid increase, on average, but this effect proved uneven; erections come easier and Herbal infusions used for induced abortion. This information may not fit your specific health circumstances. In one trial, dl-3-n-butylphthalide 400 mg orally daily (given as one 200 mg capsule twice daily) as part of a 90-day treatment regimen was used to improve outcomes in patients with acute ischemic stroke. However, more research is required to verify this effect of celery in humans. WebThe author also recommends celery seed tinctures to treat sharp headaches over the eye and temple area that last all night, and for throbbing aches in the temple. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. A Root Vegetable With Surprising Benefits, 10 Delicious Herbs and Spices With Powerful Health Benefits, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Parmesan Cheese: Nutrition, Benefits, and Uses. Here are a few more ways to add celery seeds to your diet: Interestingly, some people use ground celery seed to make tea. View abstract. So I tried it. 6 Surprising Benefits of Celery Seeds Combined with anise and saffron, celery seed extract is used to treat menstrual discomfort and reduce fluid retention(x). Celery seed oil is a supplement containing a high amount of volatile compounds known as phthalides. Promotes joint and muscle comfort*. Many delicious ingredients are also exceptionally healthy. Our team thoroughly researches and evaluates the recommendations we make on our site. Levothyroxine is used for low thyroid function. Your lithium dose might need to be changed. Effect of celery extract on thyroid function; is herbal therapy safe in obesity? Our Celery Seed Extract is concentrated and standardized to contain 85% 3-n-butylphthalide as total phthalides. Contains 75 mg celery seed/63.75 mg 3nB extract per.Celery is often called a negative calorie food but it certainly isnt lacking in nutrition. celery seed extract, fresh or dried seeds, tablets and as capsules filled with celery seed oil. Food Chem.Toxicol. Used in cooking, celery seed spice is considered likely safe in normal quantities. Natural Extracts Lower Blood Pressure - Life Extension IMPORTANT: Celery seed and celery extract should be avoided by pregnant women. Apiole has been used for centuries as an abortifacient: an herb used to cause a deliberate miscarriage. Nitric oxide is an important compound in the body, but it can produce oxidative stress and inflammation in large amounts. Inhibitory effects of, Kooti W, et al. A case of Apium graveolens (Celery) induced hyperthyroidism. However, people who take the following medicines should ask their doctors before taking celery seed. Despite their small size, celery seeds have an impressive nutrient profile. In fact, celery seeds and celery seed extract been used to treat a variety of health conditions for thousands of years. Taking celery might decrease how well the body gets rid of lithium. -selinene-rich essential oils from the parts of. Celery: Health Benefits, Nutrients, Preparation, and More With many different standardizations, the dosages may differ between supplements. Talk with your healthcare provider before using celery if you are taking lithium. If you buy through links on this page, we may earn a small commission Heres our process. Jakovljevic, V., Raskovic, A., Popovic, M., and Sabo, J. Bauer L, Ebner C, Hirschwehr R, et al. Celery juice might decrease how quickly the liver breaks down and removes aminopyrine. These benefits may also be found in the beta-selinene in celery seed, but this study didnt test celery specifically. Without enough dietary iron, your body cannot produce enough red blood cells. Other reactions that can result from handling the plant or eating large amounts of celery seeds include tiredness, slowed breathing and decreased heartbeat, warns Summit Medical Group. More importantly, celery seeds may be useful in the treatment of hypertension help normalize blood pressure.(x). It has tough, ribbed green stems and segmented dark-green leaves containing toothed leaflets. Teng CM, Lee LG, Ko SN, et al. For these reasons, you should take herbs under the supervision of a health care provider. Medically reviewed by Drugs.com. Celery seeds consist of the oil (petroselinic, linoleic, palmitic, and oleic fatty acids) and volatile compounds, mostly monoterpene hydrocarbons.Kooti 2017 The major Arch Intern Med. Though small in size, celery seeds are of great nutritional value and provide many health benefits. Atta AH, Alkofahi A. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. reduction of serum uric acid and antioxidant activity. 1985;3:85. WebCelery stem, oil, and seeds are commonly consumed in foods. Gout is triggered when uric acid builds up within the joints. Maljaei MB, Moosavian SP, Mirmosayyeb O, Rouhani MH, Namjoo I, Bahreini A. Avoid use. Nutr Cancer. As medicine, celery seed powder or extract have most often been used by adults in doses of 1000-1500 mg by Zhou Y, Taylor B, Smith TJ, Liu ZP, Clench M, Davies NW, Rainsford KD. If you have a history of heart disease, you may want to start with a lower dose of the herb. Paul Pitchford, in his book "Healing with Whole Foods," recommends celery juice combined with lemon juice to treat headaches caused by high blood pressure and excessive heat. View abstract. Hoerler, S. and Ukiwe, J. Laryngeal edema from celery allergic reaction. Wet and salty soils, swamps, and marshes are the preferred environments for celery. Ann.Gastroenterol Hepatol (Paris) 1995;31(4):256-263. Eating iron-rich food helps your body produce red blood cells and may prevent anemia. Through dietary interventions, you may be able to reduce the levels of uric acid in the blood and minimize painful flare-ups. Postgrad Med. Although the results demonstrated that celery could reduce the uric acid level in mice, no human studies have been conducted. In fact, one large review associated magnesium-rich diets with an up to 14% reduced risk of diabetes (21, 24). Ground celery seed is often referred to as celery powder. WebMD does not provide medical advice, diagnosis or treatment. Unsurprisingly, the flavor of celery seed resembles that of a celery stalk. (2017). Celery Seed Oleoresin is a natural extract derived from the seeds of the celery plant. J Ethnopharmacol. Celery Seeds: Benefits, Uses, And More Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. However, there are some safety precautions for the more concentrated forms of celery seed (31). The effects of celery leaf (apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics. Tuetun, B., Choochote, W., Pongpaibul, Y., Junkum, A., Kanjanapothi, D., Chaithong, U., Jitpakdi, A., Riyong, D., and Pitasawat, B. Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes. Other organic components include isovalerianic aldehyde, propionic aldehyde, and acetaldehyde.Christensen 2006, Garg 1980, Khan 2009, Madjarova 1979, Marongiu 2013, Nagella 2012, In in vitro studies, luteolin extracted from celery suppressed proinflammatory cytokines and upregulated cyclooxygenase expression.Christensen 2006, Kasiri 2018, Kim 2014, Park 2013 Further studies have suggested glycosides from the ethanol whole plant extract possess anti-inflammatory effects and inhibit nitric oxide production.Zhu 2017, Antifungal, antibacterial, and antiprotozoal activity has been described for celery oil.Baananou 2013, Marongiu 2013, Nagella 2012, Nguyen 2014 Activity against uropathogenic Escherichia coli bladder and kidney infections in rodents has been demonstrated.Sarshar 2018, Antioxidant activity has been demonstrated and may account for several observed effects of celery.Kooti 2017 Fresh celery flavonoid extracts reduced oxidative stress in rats and mice, as measured in the liver, mitochondria, and spermatozoa.Cao 2012, Choi 2011, Kolarovic 2010, Kooti 2014, Li 2014, Studies have focused on the role of apigenin, extracted from celery seed, as a potential chemotherapeutic agent. What Are the Benefits of Celery Seed Tea? Li S, Li L, Yan H, et al. Clin Exp Allergy 1996;26:1161-70. Available for Android and iOS devices. In an Australian study, mice suffering from arthritis and gout took a combination of Indian celery seed extract and New Zealand green-lipped mussels. Eating a magnesium-rich diet may help control blood sugar levels and reduce your risk of type 2 diabetes. Grape Seed Extract: Benefits, Side Effects, Dosage, and Interactions Yusni Y, Zufry H, Meutia F, Sucipto KW. Commercial varieties grown in North America are generally called pascal celery. In Europe, the term "celery" is frequently used to refer to a related root vegetable, A. graveolens L. var rapaceum, DC. The Celery Seed Oleoresin market's competitive landscape, key Plus, theyre available in supplemental form.You can find both the spice and celery seed supplements locally or online. If you notice negative side effects when taking herbal supplements, see your doctor. View abstract. View abstract. Incorporate them into your barbeque dishes like coleslaw or potato salad. View abstract. You can easily add celery seeds to your diet by adding them to soups, side dishes, and even hot tea. BuPh, or 3-n-butylphthalide, is a compound present in celery that improves heart health due to its lipid-lowering capabilities. Cutis 2002;70(1):29-30. Celery Am J Clin Nutr. Al-Asmari AK, et al. Taking celery root extract with venlafaxine might increase the effects and side effects of venlafaxine. An allergy to celery seed may cause rare but severe life-threatening reactions in some people. Experts advise against using celery seed supplements if youre pregnant, as it may cause uterine bleeding and even miscarriage (32, 33). Here are five reasons you should consider adding celery to your diet. Most people can safely use celery seeds in cooking. View abstract. However, bergapten may decrease potassium levels in the body and lead to muscle cramps and muscle twitching. 1994;130(6):809-810. It contains allergens that may provoke severe allergic reactions, including anaphylaxis, reports the 2017 Pharmacognosy Review study. 1992;10(6):613. 2010;48(1):93-98. Celery Seed Beier, R. C., Ivie, G. W., Oertli, E. H., and Holt, D. L. HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). Allerg.Immunol. A role for celery in cardiovascular disease, CNS disorders, gout, and diabetes has also been suggested; however, clinical studies are lacking to support a place in therapy.
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