Prolia Frequently Asked Questions (FAQs) Learn how to slow it down and fortify your body against it. See your dentist regularly. Before you have any dental work done, tell your dentist you are receiving this medicine. Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. Osteoporosis medications and medication-related osteonecrosis of the jaw. Heres a short list of some of the mild side effects that Prolia can cause. Pay special attention to your dental hygiene. 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You may need to have a negative pregnancy test before starting this treatment. Because these reports happened after the studies, it isnt known for sure whether Prolia caused hair loss, or if it was due to another reason. If youre concerned about weight gain with Prolia, talk with your doctor. They may want to check for other causes. WebMost people can get adequate calcium through their diet if they make an effort. Women Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. The drug stays in your system and continues to slow bone breakdown over this period of time. We avoid using tertiary references. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison. Terms of Use. Cleveland Clinic is a non-profit academic medical center. Your doctor can help you decide which drug is better for your needs. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. The conditions and factors to consider include: Upcoming dental procedures. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. Heres some information on pregnancy, breastfeeding, and Prolia use. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Protect from light and do not freeze. Denosumab is contraindicated in women with hypocalcaemia. for breast cancer that has not spread to other parts of the body. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. The drug could cause your calcium level to drop too low. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. These are not all the possible side effects of Prolia. High cholesterol levels can be a side effect of Prolia. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. Prolia injection is a brand of denosumab, which treats osteoporosis. or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. You should not breastfeed while using this medicine. 2023 Healthline Media UK Ltd, Brighton, UK. Prolia can cause both mild and serious side effects. If you drink alcohol, talk with your doctor about how much is safe to drink with your condition. Prolia pregnancy and breastfeeding warnings. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. If you receive Prolia, you should not receive XGEVA. Like most drugs, Prolia may cause mild or serious side effects. The drug may increase the risk of pregnancy loss. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. Tell your doctor right away if you become pregnant while taking Prolia. Prolia contains the active ingredient denosumab. Theyll discuss with you other treatments to help prevent bone loss. You may wonder how Prolia compares with the alternative drug Reclast. These medications have different active ingredients and they belong to different groups of drugs. supplements What are the possible side effects of Prolia? Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Prolia Subcutaneous: Uses, Side Effects, Interactions, Pictures Prolia (denosumab) | Dosing You may want to know how Prolia compares to the medication Tymlos. Tell your doctor if you become pregnant. As you age, your BMD is reduced, and this may increase your risk for osteoporosis. Prolia side effects: What you should know - Medical With osteoporosis, your bones become porous, meaning there are large holes within your bone tissue. Calcium Supplements You should not receive Prolia if you are allergic to denosumab, or if you Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Bring someone with you to your appointment if doing so will help you feel more comfortable. Every 6 months youll get another dose of Prolia. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. This is the drugs mechanism of action. 1 shot every 6 months could mean fewer doses. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. Some people have developed unusual fractures in their thigh bone. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. WebYou should take calcium and vitamin D as your doctor tells you to while you receive kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. For more information about how Prolia and Zometa compare with each other, see this article. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Patients in the study may take other drugs besides Prolia and Calcium. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Prolia can also increase this risk. (Biosimilars are like generic drugs. With bone loss, your body loses old bone tissue faster than it makes new bone tissue. For Xgeva, talk to your pediatrician regarding the use of this medicine in children. (2022). A solid routine can help to strengthen your muscles and bones, which helps to lower your, If you have osteoporosis, diet plays a vital role in managing your condition. They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. For instance, if you have a health condition that causes excess calcium in Also tell them if you smoke, drink alcohol, or use illegal drugs. Prolia may cause serious side effects. This is called hypocalcemia. This drug may decrease your body's ability to fight infection. You may report side effects to FDA at 1-800-FDA-1088. Although its rare, your doctor may give you the option to self-inject Prolia at home. Talk with your doctor before starting Prolia treatment. Learn more about your health after menopause. I am taking Prolia and just saw that it's important to take Calcium because Prolia takes the calcium out of the blood and that can cause problems. Prolia also carries a warning about hypocalcemia, which is a low level of Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. Our phase IV clinical studies alone cannot establish cause-effect relationship. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. For more information on this side effect, see Side effect specifics below. Since different people The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. If you have a low calcium level, you should not take Prolia. You should also take calcium and vitamin D supplements while being Generic name: denosumab (Prolia) [den-OH-sue-mab] Prolia and Forteo are both used to treat osteoporosis. All rights reserved. Its used to lower the risk of bone fractures in people with certain other conditions. Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. Now i'm wondering if i shouldn't take K2. Nonmetastatic means the cancer hasnt spread to other areas of the body. Denosumab Injection: MedlinePlus Drug Information But Prolia is given once every 6 months by a healthcare professional. If you have questions about treatment options for osteopenia or arthritis, talk with your doctor. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. WebStudies have shown that people who live more sedentary lifestyles are at an increased risk of developing osteoporosis. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Call your doctor for instructions if you miss a dose or miss an appointment for your Prolia injection. Some people may have dental or jaw-related issues with Prolia use. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. What should I know about Prolia vs. Boniva? Starting an osteoporosis drug? Here To date, the consensus is that there has been no proven risk of increased cardiovascular risk with intake of calcium supplements. It does the same thing that. Use of the terms female and male in this article refers to sex assigned at birth. This increases your risk for bone fractures. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. You are encouraged to report negative side effects of prescription drugs to the FDA. If your Prolia treatment is stopped, talk to your doctor about other medicine that If your pain becomes severe, your doctor may recommend other treatment options to replace Prolia. Call your doctor at once if you have: new or unusual pain in your thigh, hip, or groin; severe pain in your joints, muscles, or bones; skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. Prolia But weight gain may be a symptom of a side effect called peripheral edema. Continue reading, Yes, Prolia does appear to weaken your immune system. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. Theyll also discuss with you how to lower your risk for fractures by adding other treatments or making certain lifestyle or diet choices. 8,432 people who take Prolia and Calcium together, and have interactions are studied. Prolia can cause many serious side effects. Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. You can also visit the Prolia manufacturers website to see if they have support options. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. So, if you want to stop taking Prolia, talk with your doctor. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). WebAdults ages 19 through 50 should not get more than 2,500 mg calcium total per day (including food and supplements). for prostate cancer that has not spread to other parts of the body. Prolia can also cause bones to not form correctly and reduced growth in a fetus. Calcium and Vitamin D: Important Patients should not stop Prolia treatment without first consulting your Prolia may cause several side effects. All rights reserved. Talk with your doctor about your health history and discuss your risks with Prolia treatment. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. These effects are called interactions. Medication Guide. Ask your plan if they cover the drug, and what the cost will be for you. Let your doctor know if you have questions about which drug is recommended for you. * Sex and gender exist on spectrums. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. For more information, you can refer to the drugs prescribing information. Talk with your doctor or health care professional about your birth control options while taking this medicine. Dosage of drugs is not considered in the study. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. Allergic reaction. There arent any studies that have compared these two drugs to each other. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. They can tell you more about benefits and risks of Prolia and Forteo. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. Prolia isnt approved to treat osteopenia or arthritis. Weakness and tingling can also occur. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. As with most drugs, Prolia can cause an allergic reaction in some people. Stopping Prolia doesnt cause withdrawal symptoms. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. Store in the original container away from heat and light. This can cause your weight to change and may explain any weight gain since starting Prolia treatment. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments Be sure to talk with your doctor about which medication is right for you.
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