Avg. The region showing four allele combinations, where the possible SNP genotypes were BBB, BBA, AAB, and AAA, were on chromosome X (Fig. Tetragametic Chimerism," published on 16 May 2002 in The New England Journal of Medicine, in which doctor Neng Yu and a . b A B-allele frequency (BAF) plot and possible allele patterns of the patients nail DNA, showing a XX to XY ratio of 50% in SNP array analysis. 2. Although there are various mechanisms that lead to the development of chimeras, our results suggested that this patient was a parthenogenetic chimera [9]. According to the documentary, other forms of evidence of Fairchilds maternity, including photographs of Fairchild with her children throughout their lives, Townsend stating he had witnessed both childrens births, and footprint records taken from the children as neonates, were repeatedly dismissed. Jonathan, an actor, sang in cathedrals all over the world. There are some nuances in Double Jeopardy! They asserted she was committing welfare fraud by lying about her relationship with her children. A serious sexual assault has been committed and investigators are trying to find out who the perpetrator is. tetragametic chimerism jeopardy What's On Tonight & Pop Culture: Jeopardy! game show and all elements thereof, including but not limited to copyright and trademark thereto, are the property of Jeopardy Productions, Inc. and are protected under law. Jonathan dropped $7,500 to win with $22,500 for a two-day total of $51,700. We were told that is why they take that first break. J Korean Med Sci 22:553556, Gusmo L, Butler JM, Carracedo A et al (2006) DNA Commission of the International Society of Forensic Genetics (ISFG): an update of the recommendations on the use of Y-STRs in forensic analysis. We report a boy with ambiguous genitalia and hypospadias, showing 46,XY[26]/46,XX[4] in peripheral . Correct Qs: DD1 What is delta? National College Championship 2022, James Holzhauers Game-By-Game Statistics, Jason Zuffranieris Game-By-Game Statistics, Jonathan Fishers Game-By-Game Statistics, more information can be found at gamersvsms.ca. Provided by the Springer Nature SharedIt content-sharing initiative, Journal of Human Genetics (J Hum Genet) 6: 25.623% Malan V, Gesny R, Morichon-Delvallez N, Aubry MC, Benachi A, Sanlaville D, et al. In 1969, three researchers from the University of California, San Francisco, collected white blood cells from women pregnant with boys and found that some had what appeared to be a Y chromosome. - In genetic terms, a chimera is any organism that is made up of cells from at least two genetically distinct zygotes, a zygote being a fertilized egg that had tetragametic chimerism . Tetragametic chimerism; Follow this link to review classifications for Tetragametic chimerism in Orphanet. Another natural way that genetic chimeras can emerge is when two eggs get fertilized by two sperms at the same time, which would normally result in fraternal twins. tetragametic chimerism occurs through the fertil-ization of two ova by two spermatozoa, followed by the fusion of the zygotes and the development of an organism with intermingled cell lines. Jonathan $30,000 $7,500 = $22,500 (What is Penguin?) DD2 - What is Carolingian ? tetragametic chimerism jeopardy - nationalcherrymonth.com ), DD2 $2,000 EUROPEAN HISTORY Though Pippin III founded this Frankish dynasty in 751, its name comes from the many Charleses who ruled it (Robinson-Gissette won the table limit of $2,000. Jerome Vered $499,102 He was a genetic chimera. For more information, please see our Having the higher value clues take place when your buzzer familiarity advantage is greatest is an advantage for the champion. 6. From the blood alone, these two brothers were now identical twins. From these results, we concluded that this XX/XY chimera is composed of two different paternal alleles and a single duplicated maternal genome. Ken Jennings $2,520,700 But there are interesting cases where the developing embryo becomes a sort of chimera. ), FJ - PUBLISHING - Last name of brothers James, John, Joseph & Fletcher, whose co. published magazines with their name as well as books. Advances in Forensic Haemogenetics 6:174176, Fracasso T, Schrenkamp M, Brinkmann B, Hohoff C (2008) An X-STR meiosis study in Kurds and Germans: allele frequencies and mutation rates. This raised a bunch of red flags with the legal systemwhos kids are these, were they kidnapped, etc. That officer later witnessed the neonate being delivered from Fairchilds body and watched as doctors drew blood from both Fairchild and the infant. In The Twin Inside Me, researchers speculate that Keegan and Fairchild were both chimeras, resulting from the fusion of two independently fertilized eggs at a very early stage of development. satoru iwata death reaction. A genomic view of mosaicism and human disease. Article Clinical findings of the patient. If it contained white blood cells (as red blood cells in mammals lose their DNA as they mature), you temporarily had someone elses DNA flowing through your veins. The XX/XY chimera is classified into some subtypes; tetragametic chimeras [2,3,4,5], parthenogenetic chimeras [5,6,7,8,9], androgenetic chimeras [5, 10, 11] and sesquizygotic twinning chimera [12]. 5: 49.987% Background: The case of a healthy woman with serologic blood group AB and her biologic father showing blood group O was investigated. A 41-year-old healthy Caucasian male showed an unidentifiable direct AB0 group and a B group by an indirect method revealing the presence of natural antibodies anti-A1 and anti-A2. 78 correct, 7 incorrect A breakthrough came when her defense attorney,[1] Alan Tindell, learned of Karen Keegan, a chimeric woman in Boston, and suggested a similar possibility for Fairchild and then introduced an article in the New England Journal of Medicine about Keegan. After all, DNA doesnt lie, right? To confirm chimerism, we carried out SNP microarray analysis using a CytoScan 750K Array (Affymetrix, Santa Clara, CA). Tetragametic chimerism (Concept Id: CN200724) - National Center for Privacy Policy. Did you know that you can now find game-by-game stats of everyone, now including Jason Zuffranieri and James Holzhauer, who has won 10 or more games on Jeopardy!, here on the site? 23. Bone Marrow Transplant 26:219224, Bader P, Niethammer D, Willasch A, Kreyenberg H, Klingebiel T (2005) How and when should we monitor chimerism after allogenic stem cell transplantation? An organism gets approximately half of its DNA from each of its parents gametes, or their sperm and egg cells, which carry DNA from parent to offspring. Brittany $4,400 Hum Mol Genet. A 41-year-old healthy Caucasian male showed an unidentifiable direct AB0 group and a B group by an indirect method revealing the presence of natural antibodies anti-A1 and anti-A2. This indicates the presence of two different genomes, demonstrating that the patient does not show mosaicism but is an XX/XY chimera. On the other hand, careful follow-up of testicular function is important in considering future family planning and gender identity for the patient. Has DNA gone mad? Molecular support for heterogonesis resulting in sesquizygotic twinning. Because of the induction date, Fairchild requested that the court postpone the case until after they tested the DNA of her third child. Blood 91:16871694, Article Bone Marrow Transplant 35:107119, Bolan CD, Leitman SF, Griffith LM et al (2001) Delayed donor red cell chimerism and pure red cell aplasia following major AB0-incompatible nonmyeloablative hematopoietic stem cell transplantation. This list may not be comprehensive and may include broader topics as well. The woman, singer Taylor Muhl, has a condition called chimerism, meaning she has two sets of DNA, each with the genetic code to make a separate person. This was clearly impossible to her, but this uncanny result was not due to a sample mix-up in the lab. Chimeras are organisms that have two different sets of DNA, or the genetic material that contains instructions for the development and functioning of an organism, present in their bodies. After all, DNA doesnt lie. According to the documentary, US courts at the time accepted DNA evidence as infallible, meaning it was seldom contested in a court of law. When Fairchild applied for enforcement of child support in 2002, providing DNA evidence of Townsend . We found both a region showing five allele combinations, where possible SNP genotypes were BBBB, BBBA, BBAA, BAAA, and AAAA, which means that there were three or four chromosome sets, and a region showing three allele combinations, where the possible SNP genotypes were BBBB, ABAB, and AAAA, which means that there were two identical chromosome sets in the autosomes (Fig. 25. In medical terms, this cross-connection is known as an anastomosis. It divides into two, making copies of these chromosomes, and we think that every cell down the line ends up with the same genetic bundle. Triple Stumper of the day: If the players focused on the last six words of this lengthy clue, they likely would have known that "the short route between 2 points" is a straight line. 3/4 on rebound attempts (on 11 rebound opportunities) tetragametic chimerism jeopardy contestant. Sex-chromosome discordant chimerism (XX/XY chimerism) is a rare chromosomal disorder in humans. Number of clues left unrevealed this season: 1 (0.05 per episode average), 0 Daily Doubles, Game Stats: FJ - What is Harper? Brittany $5,200 It affects less than 5% of cells, and as such is not considered complete chimerism. d Testis biopsy of the patient (left). Walsh correctly answered "It" (by author Stephen King), ending the show with $18,800 for a four-day total win of $81,700. However, we know that 20 to 30 percent of singleton pregnancies were originally a twin or a multiple pregnancy. 22. However, in some cases, those two fertilized eggs may fuse together during an early stage of development, resulting in a chimera made of two genetically distinct cell lines. 2c). (2-day total: $51,700), Scores after the Jeopardy! Lydia Fairchild (born 1976) is an American woman who exhibits chimerism, having two distinct populations of DNA among the cells of her body. Schematic drawing of how a parthenogenetic chimera is produced. That means these families of cells are genetically different, and because DNA is a blueprint, it can result in interesting physical manifestations. A case of a parthenogenetic 46,XX/46,XY chimera presenting ambiguous genitalia. Jonathan $9,000 Disputed Maternity Leading to Identification of Tetragametic Chimerism Am J Med Genet A. All this talk of genetic anomalies and quirks brings us right back to Alaska. a Smooth signal track of the patients X chromosome. Once Fairchilds mother submitted her DNA in comparison, matching as the maternal grandmother of the children, the judge dismissed the case, admitting he was wrong. Actually Mayim was holding the cue card or clue card and when she moved it you could see Final Jeopardy. 2012;13:85. Fairchild appeared in court on a Friday. Int J Legal Med 123, 431435 (2009). All I can think of is that the contestants are given backup cards to write on in case their light pen fails and Brittany was just holding one of those up, maybe? J Med Genet. Ray Lalonde $386,400 Since Jeopardy only keeps auditions until the end of the season, Earl didn't get a chance to play due to Ken's long streak CAS We report a boy with ambiguous genitalia and hypospadias, showing 46,XY[26]/46,XX[4] in peripheral blood cells. Robinson-Gissette spoke in their interview about having tetragametic chimerism. - 62.210.204.69. c The ultrasound echoic level of both gonads was homogeneous. This condition is called tetragametic chimera. Jonathan 29000 +1000 (Brittany 5200 Robinson-Gissette 3600) how to bet in Final Jeopardy? In 2002, after applying for government assistance in the state of Washington, Lydia Fairchild was told that her two children were not a genetic match with her and that therefore, biologically, she could not be their mother. To solve this puzzling case, we need to appreciate mythical beasts. J Assist Reprod Genet. James Holzhauer $2,462,216 The seminiferous tubules appeared dysplastic, but detailed analysis demonstrated that they were not dysplastic. Next, to confirm chimerism, we analyzed the B-allele frequency of autosomes and the X chromosome [13, 14]. Different molecular studies have confirmed this mechanism ( Green et al. 3/4 on Daily Doubles (Net Earned: $3,600) Jonathan dropped $7,500 to win with $22,500 for a two-day total of $51,700. Clue selection strategy: With Matt gone, we saw a return to mostly top-down play in round one, although in DJ, clue selection became more varied. 4. A similar case a few years later was much more unpleasant. After receiving approval from the Ethics Review Board for Human Genome Studies at Fujita Health University and written informed consent from the parents to participate in our study, genetic diagnosis was performed. Heres todays Final Jeopardy (in the category Publishing) for Tuesday, October 12, 2021 (Season 38, Game 22): Last name of brothers James, John, Joseph & Fletcher, whose co. published magazines with their name as well as books, (correct response beneath the contestants). Kaye acknowledges that human chimerism should be a consideration in DNA testing, given its unknown frequency, but rejects the statement that it is a significant obstacle to its use in forensic investigation. In the meantime, to ensure continued support, we are displaying the site without styles F. De Stefano. . Each time, the results indicated that Fairchild was not the biological mother of the two children. Jeopardy! Krimsky and Simoncelli also stated that potentially every human being could exhibit some trait of chimerism, which they claim may impact the way that forensic scientists collect and utilize DNA in crime scene investigations. All rights reserved.. Powered by, Community Guidelines & Contact Information. 2. 10 correct, 7 incorrect and our Some cells come from sperm 1 and egg 1, while the rest come from sperm 2 and egg 2. 7. Article FISH showed nuc ish XX[83]/XY[17]. Jonathan is a one-day champ with winnings of $29,000. She was a monstrous creature, a hybrid of many animals, ultimately slayed by the hero Bellerophon. David Madden $773,733 If you are going to quote any information from this page or this website, attribution is required. Ryan Long $299,400 So, the father asked for a paternity test. Alex was just as you saw him for the next 34 years: friendly, courteous, extremely knowledgeable, curious, and most of all, had a playful and sly sense of humor! Int J Legal Med In press. Kaiser-Rogers KA, McFadden DE, Livasy CA, Dansereau J, Jiang R, Knops JF, et al. https://doi.org/10.1007/s00414-009-0332-0, DOI: https://doi.org/10.1007/s00414-009-0332-0. 1). One more thing: For the first time this season, the players got the one-minute warning in DJ and there was a leftover on the board. An Italian database of 4 co-amplified STRs loci. Part of me feels like the EUROPEAN HISTORY $400 clue about the Guelphs and the Ghibellines was a bit of a callback to my, Robinson-Gissette spoke in their interview about having. I heard an interesting story about chimerism. 2016;3:194204. How did a criminal escape from jail to commit sexual assault, only to quickly return behind bars? We chose STR markers located in the region showing the five allele combinations in autosomes or four allele combinations on chromosome X on SNP array analysis. , 1995 ; Bonthron, 1997 ; Strain et al. 3 (2016, identifying 36 SNPs shared with the SNP array chip.Both NGS data from the blood and the skin DNA samples were collected thus determining the genotypic layout in both tissues. Dan Pawson $430,902 Jeopardy! recap for Tue., Oct. 12 - Blogger Jonathan is a one-day champ with winnings of $29,000. 11. The blue and red colored chromosomes in the circles are both of paternal origin. Jeopardy! You were a momentary chimera. Anytime Test; Prep Center; Take the Practice Test; Contestant FAQs; Games & More. SNP array and STR analysis. J!6; J!6 Alexa; Infinite Final J! Proceeds from the sale of the Doctor Ozs Fast-Acting Snake Oil Elixir T-shirt are being donated to The Trevor Project: Looking to find out who won Jeopardy! Finally, a lawyer did take her on as a client and stumbled upon the Keegan case as reported in the New England Journal of Medicine. Researchers later determined that the genetic mismatch was due to chimerism, a condition in which two genetically distinct cell lines are present in one body. Google Scholar. Matt Jackson $611,612 Slider with three articles shown per slide. Conlin LK, Thiel BD, Bonnemann CG, Medne L, Ernst LM, Zackai EH, et al. We used genomic DNA, which was isolated from nail as a template for microarray analysis. 2a). No other tissue-like structures with margins, suggestive of ovarian tissue, were detected. https://doi.org/10.1038/s10038-020-0748-4, DOI: https://doi.org/10.1038/s10038-020-0748-4. Average Coryat: $22,200, Brittany Iburg, career statistics: 7: 24.987% If Keegan had been a chimera, might Fairchild not be one too? Except they were not. More information about Final Jeopardy: (The following write-up is original content and is copyright 2021 The Jeopardy! The court suggested placing her two children in separate foster homes while the case was contested to monitor the childrens wellbeing, since officials assumed that Fairchild was being fraudulent about her relationship with the children. Correspondence to Jonathan is a one-day champ with winnings of $29,000. 1), suggesting that the chimera is possibly tetragenic, parthenogenic or androgenic. Compared to control tissue (right, age-matched normal testis), interstitial tissue of the patient was edematous and more prominent than the seminiferous tubules, which were tortuous and diverging. in 1986, third show of the third season. Correct Qs: DD1 - What is delta? Jeopardata; This Week on Jeopardy! Its the one that happens during pregnancy. Mark Dawson $343,849, Copyright 2023 | MH Newsdesk lite by MH Themes. J! This so called tetragametic chimerism occurs via the fertilization of the two ova by two spermatozoa, followed by the fusion of early embryos and the development of an organism with intermingled cell lines. Robinson-Gissette, an art assistant, has tetragametic chimerism; Brittany, a stay-at-home mom, backpacked along the bottom of the Grand Canyon; and. A tetragametic chimera thus has two main types of cells making up their body. Actor Jonathan ran a category about directors early in DJ and never had an anxious moment, leading into FJ with $30,000 vs. $5,200 for Brittany and $3,600 for Robinson-Gissette. Given all these different ways of creating human chimeras, what is the overall definition of chimerism? By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. The prosecutors office in the state of Washington took over Fairchilds case suspecting welfare fraud. 17. Tetragametic chimeras can have what doctors refer to as atypical genital appearance, although not all intersex people are chimeras, and not all chimeras are intersex. Robinson-Gissette $3,600, Tonights results: a Schematic drawing of how a parthenogenetic chimera is produced. 2) EUROPEAN HISTORY $2000 (clue #9) In 2002, Fairchild was at the end of her third pregnancy with Townsend. A bit disappointed but not surprised that weve gone back to starting at the top row. However, Kaye states that those forms of chimerism would not affect how DNA is left in crime scenes. If you are going to quote any information from this page or this website, attribution is required. Amy Schneider $1,632,800 Roger Craig $555,200 We would also like to thank Dr Akiko Helena Popiel for valuable comments, Tatsuro Ikeda for drawing of the Figures. When commenting, please note that all comments on The Jeopardy! DD1 - $400 - & PLAYING TRIANGLE - The ancient Greeks compared the constellation Triangulum to this capital letter of theirs (Brittany doubled to $2,800. Check out my new Betting Strategy 101 page! Mechanisms of mosaicism, chimerism and uniparental disomy identified by single nucleotide polymorphism array analysis. The XY/XX ratio in buccal cells (17%) was lower than that in peripheral blood cells (87%). That is due to the fact that Fairchild and Keegan exhibit two DNA lines only in very specific areas of their bodies, and only at a microscopic level. J Med Genet. Contestants; Contestant Zone. We often think of inheritance in simple terms: my parents had it, therefore so do I. Endoduplication of the maternal genome occurs just before fertilization with two spermatozoa. Tetragametic chimerism appears to be rare. Prenatal diagnosis and normal outcome of a 46,XX/46,XY chimera: A Case How had he escaped, committed the crime, and returned to jail undetected? Julia Collins $494,767 Scan data were visualized using ChAS 3.2 software (Affymetrix). Lydia Fairchild was applying for public assistance to help support her family, and testing was required to prove that her children were indeed related to her. Following evidence from another case of chimerism documented in The New England Journal of Medicine in a woman named Karen Keegan, Fairchild was able to secure legal counsel and establish evidence of her biological maternity. Due to this statistic, it is quite possible that tetragametic chimerism is more common than current data implies. Google Scholar, Cho D, Lee SK, Yazer MH et al (2007) A dispermic chimera with mixed field blood group B and mosaic 46, XY/47, XYY karyotype. DD2 What is Carolingian ? Am J Hum Genet. Brad Rutter $4,953,436 These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. The type of chimerism that that they have means that they most likely have two complete sets of DNA. Ive also heard of people having differing DNA in the blood and tears. Ill be doing my shift as part of the relay on Thursday, October 21 from 2:00 AM to 8:00 AM EDT on my own Twitch channel, twitch.tv/andythequizzer/. Parthenogenetic chimaerism/mosaicism with a Silver-Russell syndrome-like phenotype. G-banding from peripheral blood cells of the patient showed 46,XY[26]/46,XX[4]. DNA testing established that the children were indeed siblings but concluded that she was not their mother. 8: 17.666% Tetragametic chimerism is a rare, sex chromosome disorder of sex development characterized by the two different haploid sets of maternal and paternal chromosomes and variable phenotype - from normal male or female genitalia, to different degrees of ambiguous genitalia, and often infertility. DD3 - What is veterinarian? After separating from her childrens father, Fairchild applied for state assistance, a process that required both paternity and maternity tests. The company merged with Row, Peterson & Company to become Harper & Row in 1962, and, after a purchase by NewsCorp in 1987, merged with William Collins, Sons in 1990 to become HarperCollins. This is an interesting question to contemplate, because it allows us to distinguish chimerism from another, very similar genetic anomaly. This occurs when two separate ova are fertilized by two sperm and produce two zygotes. PubMed 0/1 on Daily Doubles (Net Earned: -$1,000) Hum Reprod 21:579591, Drexler C, Glock B, Vadon M et al (2005) Tetragametic chimerism detected in a healthy woman with mixed-field agglutination reactions in AB0 blood grouping. Copyright Arizona Board of Regents Licensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/, https://abcnews.go.com/Primetime/shes-twin/story?id=2315693, http://nsuworks.nova.edu/cgi/viewcontent.cgi?article=1037&context=law_facarticles, https://academic.oup.com/humupd/article/5/2/179/562946, https://www.youtube.com/watch?v=dFf5gKiTGlo&vl=en, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684380/, https://conservancy.umn.edu/bitstream/handle/11299/144217/Chimeric-Criminals-by-David-Kay_MN-Journal-Law-Science-Tech-Issue-14-1.pdf, https://www.scientificamerican.com/article/3-human-chimeras-that-already-exist/, https://www.mayoclinic.org/healthy-lifestyle/getting-pregnant/expert-answers/ovulation-signs/faq-20058000, https://www.nejm.org/doi/full/10.1056/NEJMoa013452, Arcabascio, Catherine. Bottom, whereas G-banding from the peripheral blood cells of the patient showed 46,XY[26]/46,XX[4] (XX:XY ratio, 1:9), FISH showed nuc ish XX[83]/XY[17] (XX:XY ratio, 8:2) in buccal cells, and the SNP array suggested that both XX and XY are present at about 50% (XX:XY ratio, 5:5). DNA analysis of tissues revealed a tetragametic chimerism due to an apparent double parental contribution of nuclei in a phenotypically normal man. Jonathan is a one-day champ with winnings of $29,000. Since they tape 5 shows a dayor at least did so back thenall 11 of us first spent 5 hours in short practice games, so they could work on the monitors, sound systems, lighting, etc. What these cells do, if anything, remains unclear, but some findings point in the direction of non-negligible health effects for fetal microchimerism. Total Left On Board: $1,200 In the late 1990s, a fifty-two-year-old woman named Karen Keegan needed a new kidney due to renal failure, so she and her familyincluding her children, cruciallywere tested to see if a biologically compatible kidney was available. When the marrow recipient was arrested, his blood was collected and its DNA was entered into the database, where it proved a match during the sexual assault case. Robinson-Gissette $3,600 $3,600 = $0 (What is Pilii (Pulitzer)) Once again, even though the court-appointed witness saw this child come out of her body, the child did not match her DNA. "Chimeras: double the DNA-double the fun for crime scene investigators, prosecutors, and defense attorneys. The Avocado uses cookies to help us with usage statistics. They also found that, although the DNA in Fairchild's skin and hair did not match her children's, the DNA from a cervical smear test did match. Average Coryat: $15,200, To win: 19. It helped renew my interest in genetics and in its real-world applications. And you are spot on! Gabbett MT, Laporte J, Sekar R, Nandini A, McGrath P, Sapkota Y, et al. International Journal of Legal Medicine The use of DNA in courts relies on the belief that there is a direct connection between a DNA sample and the person it is taken from. ISSN 1434-5161 (print), A case of a parthenogenetic 46,XX/46,XY chimera presenting ambiguous genitalia, https://doi.org/10.1038/s10038-020-0748-4, Haplotyping-based preimplantation genetic testing reveals parent-of-origin specific mechanisms of aneuploidy formation, Novel pericentric inversion inv(9)(p23q22.3) in unrelated individuals with fertility problems in the Southeast European population, Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes, Mosaic Turner syndrome shows reduced penetrance in an adult population study, Microdeletions and microduplications linked to severe congenital disorders in infertile men, Parental contribution to trisomy in heterozygous androgenetic complete moles, Androgenetic chimerism as an etiology for BeckwithWiedemann syndrome: diagnosis and management, Comprehensive copy number analysis of Y chromosome-linked loci for detection of structural variations and diagnosis of male infertility, Evidence for nonhomologous meiotic coorientation in man, Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts.
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