Anticancer. European Hematology Association (EHA) and European . S.M. Symptoms and signs of 75 patients with hypersensitivity reactions to carboplatin. This exciting partnership delivered a unique cancer congress in Europe with huge scientific reach and the true potential to improve the lives of cancer patients. Federal government websites often end in .gov or .mil. 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All funding for this site is provided directly by ESMO. Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan. Incidence and intensity of anaphylaxis/hypersensitivity events: Table: 138P. 8600 Rockville Pike This was the largest series of gynecological malignancies investigated for carboplatin-related hypersensitivity reactions. ESMO Colloquia are innovative sessions within the Congress programme, organised by ESMO and supported by industry, Information about the exhibition and Satellite Symposia, Contact details and welcome message, plus other general information about ESMO 2017. Among cases developing carboplatin-related hypersensitivity reactions, the median number of cycles is 912, and the median doses 6,0008,000 mg. Reported risk factors for carboplatin-related hypersensitivity reactions include carboplatin cycle/dose, platinum-free interval, and history of drug allergies (Libra et al., 2003; Confino-Cohen et al., 2005; Schwartz et al., 2007; Koshiba et al., 2009). The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Clinical features of hypersensitivity reactions to carboplatin. Lancet 361, 20992106. Clinical practice guidance in a modernised format that focuses on visual representation of recommendations for quick and easy reference by practicing clinicians. Bayer to Highlight New Research at ESMO 2017 Congress Severe reactions are less frequent and may be fatal without appropriate intervention. doi: 10.1159/000055363, Pujade-Lauraine, E., Wagner, U., Aavall-Lundqvist, E., Gebski, V., Heywood, M., Vasey, P. A., et al. Galateanu B, Pucau AI, Tircol SA, Tanase BC, Hudita A, Negrei C, Burcea-Dragomiroiu GT, Negreanu L, Vacaroiu IA, Ginghin O. Int J Mol Sci. -. Ann. Oncol. 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Accessibility Multivariate analysis was conducted using logistic regression to estimate the association between the potential risk factors and the occurrence of hypersensitivity. (2009). S M S, Naveen NR, Rao GK, Gopan G, Chopra H, Park MN, Alshahrani MM, Jose J, Emran TB, Kim B. Supportive and Palliative Care | ESMO National Library of Medicine J. Gynecol. The tests were analyzed at an accredited lab according to protocol. Gynecol. (2010). Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (2017) 8 Pager Instructions Coverage Begins March 1, 2019 Coverage Ends: TBD 1. . TABLE 3 Table 3. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. (33)]. It would be worthwhile to evaluate the correlation between other HRD genes and carboplatin hypersensitivity. An official website of the United States government. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Int. Analysis of patients with epithelial ovarian cancer or fallopian tube carcinoma retreated with cisplatin after the development of a carboplatin allergy. Zhi. All funding for this site is provided directly by ESMO. Epub 2011 Jan 26. Desensitization is a high risk procedure in which a drug is administrated to a patient who has already presented an allergic reaction, almost always severe. However, 48 (78.7%) of these patients developed repeated hypersensitivity reactions, even after pre-treatment with intravenous antihistamines, H2 blocker, and corticosteroids prior to carboplatin re-administration. Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies. Among these 75 women, 16 (21.3%) experienced severe hypersensitivity reactions (grades 3 and 4). Integrating science into oncology for a better patient outcome, ESMO Designated Centres Community Session, Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. Cancer 15, 1318. WHIPPANY, N.J., Sept. 1, 2017 /PRNewswire/ -- Bayer will present the latest research from across its growing oncology portfolio at the European Society for Medical Oncology (ESMO) 2017 Congress . Cisplatin may be a valid alternative approach in ovarian carcinoma with carboplatin hypersensitivity. ESMO Call to Action on COVID-19 Vaccinations and Patients with Cancer: Vaccinate. EHA Endorsement of ESMO Clinical Practice Guidelines for Dia - LWW Pharmacol. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel on patients with optimally resected stage III ovarian cancer: a gynecologic oncology group study. There is a need to further characterise risk of anaphylaxis/hypersensitivity with PH IV/PH FDC SC to support safe administration outside of clinics. This site uses cookies. The MASCC/ESMO guidelines recommend that patients receiving HEC are given a dose of 20 mg dexamethasone on Day 1 to prevent acute emesis; however, if the NK 1 RAs aprepitant or netupitant are also used, a reduced dose of 12 mg dexamethasone is recommended. Webcasts and presentations from ESMO 2017 can be accessed by ESMO members and event attendees. 2017;40(3):120-127. doi: 10.1159/000458443. This site uses cookies. We analyzed the relationships among the incidence, characteristics, risk factors, management, and outcomes of carboplatin-related hypersensitivity reactions in this patient population. Accessibility J. Clin. Successful carboplatin desensitization in patients with proven carboplatin allergy. Patients feel psycho-social impact of chemo m | EurekAlert! Int. Carboplatin hypersensitivity. Oncol. doi: 10.1111/cas.12538, Kandel, M. J., Loehr, A., Harter, P., Traut, A., Gnauert, K., and du Bois, A. Table 3. eCollection 2022. Markman et al. Check the latest publications and updates here to make sure you dont miss anything. A total of 59 women experienced mild signs and symptoms (grades 1 and 2), including skin rash (69.3%), skin itching (64.0%), facial flushing (56.0%), dyspnea (41.3%), chest pain (25.3%), tachycardia (18.7%), paresthesias (16.0%), abdominal cramping (13.3%), and diaphoresis (12.0%). 21, 31943200. HHS Vulnerability Disclosure, Help Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report. Platinum desensitization in patients with carboplatin hypersensitivity: a single-institution retrospective study. Int. Bookshelf Gynecol. 28, 33233329. This site uses cookies. (2003). 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Oncol. B., Phillips, P. C., Kang, T. I., et al. Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century. Epub 2017 Feb 24. To assist those using and/or evaluating the ESMO Guidelines, download the methodology here, Download the new version of our App with the latest Pocket Guidelines for oncology professionals. Death from anaphylaxis to cisplatin: a case report. We found a higher incidence of carboplatin-related hypersensitivity among patients with advanced disease (stage IIIIV) with serous carcinoma and malignant ascites. 24, 46994707. Cancer 109, 10721078. Please enable it to take advantage of the complete set of features! Int J Med Sci (2011) 8(4):3328.10.7150/ijms.8.332 Van Tine BA, Govindarajan R, Attia S, Somaiah N, Barker SS, Shahir A, Barrett E, Lee P, Wacheck V, Ramage SC, Tap WD. Carboplatin is among the most commonly used chemotherapeutic agents for ovarian, fallopian tube, and primary peritoneal cancer, as it is active against these types of cancers with usually well-tolerated side effects (Ozols et al., 2003; Parmar et al., 2003; Pfisterer et al., 2006; Pujade-Lauraine et al., 2010). However, prolonged carboplatin use is associated with an increased incidence of carboplatin-related hypersensitivity reactions (Markman et al., 1999; Wang et al., 2009). 2022 Mar 30;9(4):26. doi: 10.3390/medicines9040026. Furthermore, patients with carboplatin hypersensitivity had a higher incidence of previous allergic history to other cytotoxic drugs, including gemcitabine, paclitaxel, and doxorubicin, compared to those without (12/75 vs. 30/660, P < 0.001, chi-squared test; Table 7).
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