Adverse reactions include burning, pain, thrombophlebitis, tissue necrosis, and gangrene. In 1987, Sterchele5 described the Hargoli S, Farid J, Azarmi SH, Ghanbarzadeh S, Zakeri-Milani P. Indian J Pharm Sci. WebPROMETHAZINE (proe METH a zeen) prevents and treats the symptoms of an allergic reaction. Allergic conjunctivitis due to inhalant allergens and foods. Paradoxical Reactions Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Pregnancy Tests If you are allergic to this medicine (promethazine suppositories); any part of this medicine (promethazine suppositories); or any other drugs, foods, or substances. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. The following laboratory tests may be affected in patients who are receiving therapy with promethazine HCl: In anesthetized rats, the plasma indomethacin levels were markedly lower than those in conscious rats, and the influence of the storage temperature on the plasma indomethacin levels was clearly observed. If you have questions about side effects, call your doctor. Preoperative, postoperative, or obstetric sedation. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. WebTo insert a promethazine suppository, follow these steps: If the suppository feels soft, hold it under cold, running water for 1 minute. It is used to ease pain . Parenteral: 25 mg IM or IV once, and may be repeated within 2 hours if necessary WebA stability-indicating GLC method for the analysis of promethazine hydrochloride in polyethylene glycol delivery systems is reported. Use of Promethazine HCl Suppositories in patients with compromised respiratory function (e.g., COPD, sleep apnea) should be avoided. Biochemical Data Summary. Nonteratogenic Effects Promethazine HCl Limited data suggest that use of promethazine HCl during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn. Once warmed, remove from wrapper and insert high into the posterior vaginal fornix. Monoamine Oxidase Inhibitors (MAOI) Promethazine is used with other medications to treat anaphylaxis (sudden, severe allergic reactions) and the symptoms of the common cold such as sneezing, cough, and runny nose. Tell your doctor or pharmacist about all the medications your child is taking, especially barbiturates such as phenobarbital (Luminal), medications for anxiety, narcotic medications for pain, sedatives, sleeping pills, and tranquilizers. official website and that any information you provide is encrypted WebWhen promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 30 days. The site is secure. FOIA pharmacist if you have questions about the best way to throw out drugs. Rectally administered indomethacin should be used with caution in patients with hemorrhoids, anal, or rectal inflammation. Minor transfusion and/or amelioration of allergic reactions may be controlled with 25 mg doses. Pre- or postoperative use: 25 to 50 mg IM or IV once Avoid prolonged exposure to the sun. Promethazine HCl in 12.5- to 25-mg doses for children and 50-mg doses for adults the night before surgery relieves apprehension and produces a quiet sleep. Preoperative, postoperative, or obstetric sedation. Promethazine HCl Suppositories are contraindicated for use in pediatric patients less than two years of age. Active and prophylactic treatment of motion sickness. <> Atropine-like signs and symptoms-dry mouth, fixed, dilated pupils, flushing, as well as gastrointestinal symptoms-may occur. 2013 Mar;75(2):143-8. Get Label RSS Feed, The product's dosage form is suppository and is administered via rectal form. Do not take a double dose to make up for a missed one. Federal government websites often end in .gov or .mil. An official website of the United States government. Would you like email updates of new search results? Promethazine can interfere with the results of home pregnancy tests. hUV?Rr$F/~H>d'K[U[\6 n=>r,+wk2rP#hqB8&\,d `S6XGfRFLm1b%Ux/w4 *uU=pk6M;]-I%d.@TdzJ]C//RbU=8q]W0,75ni. Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. When promethazine is used to treat or prevent nausea and vomiting it is usually taken every 4 to 6 hours as needed. 25 mg, white, bullet-shaped suppository wrapped in silver foil. Keep out of the reach of children. On longer trips, promethazine is usually taken in the morning and before the evening meal on each day of travel. Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of promethazine HCl suppositories and observed closely. Promethazine HCl Suppositories are contraindicated for use in pediatric patients less than two years of age. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. Promethazine HCl Rectal Suppositories are contraindicated for children under 2 years of age (see Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. Promethazine HCl Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. 0713-0536-10, Careers. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment Protect the medication from light. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal/perineuronal infiltration. help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. government site. Do not take more or less of it or take it more often than prescribed by your doctor. Many times this medicine (promethazine suppositories) is taken on an as needed basis. Comments: 2 years and older: Tell your doctor if any of these symptoms are severe or do not go away: Some side effects can be serious. If you take this medicine (promethazine suppositories) on a regular basis, take a missed dose as soon as you think about it. To report SUSPECTED ADVERSE REACTIONS, contact Cosette Pharmaceuticals, Inc. at 1-800-922-1038 or FDA at 1-800-FDA-1088 or, Promethazine HCl Rectal Suppositories are contraindicated for children under 2 years of age (, All Drug Oxidative degradation of pharmaceutically important phenothiazines III: Kinetics and mechanism of promethazine oxidation. Files, All Mapping Adjunctive therapy to epinephrine and other standard measures for anaphylactic reactions, after acute manifestations have been controlled, Parenteral: 6.25 to 12.5 mg IM or IV every 4 hours a day, Oral and Rectal: 12.5 to 25 mg orally or rectally 2 times a day. 03/2020 VC7409, Boxed Warnings, & Articles, All Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. Promethazine HCl, a phenothiazine derivative, is designated chemically as 10 SEVERE TISSUE INJURY, INCLUDING GANGRENE: Parenteral formulations can cause severe chemical irritation and damage to tissues regardless of the route of administration. Dermographism. Older adults should not usually take promethazine because it is not as safe as other medications that can be used to treat the same conditions. continuous twisting movements of the hands and feet, wide pupils (black circles in the middle of the eyes), difficulty falling asleep or staying asleep, hallucinations (seeing things or hearing voices that do not exist), overwhelming or unmanageable fear or emotion, uncontrollable shaking of a part of the body, sore throat, fever, chills, and other signs of infection, inability to respond to people around you, swelling of the face, eyes, lips, tongue, throat, arms, hands, feet, ankles, or lower legs. Promethazine HCl Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. 301-657-3000. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma. When promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. Available for Android and iOS devices. Promethazine comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally.When promethazine is used to treat allergies, it is usually taken one to four times daily, before meals and/or at bedtime. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. tablet. Webtype of IVPB solution will be stored at room temperature (21C), 4C, and 37C in the dark. 1972 Dec;24:Suppl:133P-134.
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